Konstantina’s PhD paper is out today in Biology Open. They show that, in C. elegans, the combined action of multiple bHLH transcription factors is required to activate terminal selectors beyond a certain threshold that can then regulate downstream effector genes. Congratulations!
Konstantina Filippopoulou is our first post-doc! She did her PhD at Institut de Biologie du Développement de Marseille in the lab of Vincent Bertrand studying mechanisms that ensure the robustness of neuronal specification.
We publish today in Developmental Biology a review introducing and summarizing all single-cell sequencing studies from the Drosophila visual system. We suggest ways to take full advantage of the available datasets. We discuss the state-of-the-art regarding neuronal identity regulation, neuronal circuit development and evolution of neuronal diversity. Link
The Fly Cell Atlas paper is out! The FCA consortium sequenced, annotated, and analyzed every single cell from an adult fly. This is the first whole-organism single cell atlas and is available to anyone. LinkData
Marques et al describe the very first steps of neuronal maturation in the Drosophila central brain. They show that while ChAT (choline acetyltransferase) is transcribed very early, its translation is delayed and coordinated by the developmental stage of the animal. Link
We published today in Biorxiv the complete temporal series of transcription factors in the Drosophila medulla neuroblasts. We identify the genetic interactions between the temporal transcription factors (tTFs) that allow the series to progress. We show how the tTFs regulate neuronal identity transcription factors and describe the very first steps that a neuron takes to differerentiate. Link